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Search Results for " tumor protein p53 "

Targets Recommended: Others

12

抑制剂 & 化合物

31

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
TP2299	tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]	Others	Others
	Tumor protein p53 binding protein (53BP1) has been identified in a yeast two-hybrid screen as a protein that interacts with the central DNA–binding domain of p532. Similar to breast cancer susceptibility gene 13, 4 (BRCA1; 53BP1 enhances p53-dependent tra
T3184	Kevetrin hydrochloride Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride	Mdm2; p53	Apoptosis
	Kevetrin hydrochloride (4-Isothioureidobutyronitrile hydrochloride) 是一种小分子，是肿瘤抑制蛋白 p53 的激活剂，具有潜在的抗肿瘤活性。
T72026	p53-MDM2-IN-1	Mdm2; p53	Apoptosis
	p53-MDM2-IN-1 (Example 30) 是一种 p53-MDM2/X 蛋白相互作用的抑制剂，Ki 值为 23.35 µM。p53-MDM2-IN-1 能用于抗肿瘤研究。
T28038	Milademetan HCl (1398568-47-2 free base) Milademetan HCl,DS3032,DS 3032,DS-3032,DS3032b,DS-3032b,DS 3032b
	Milademetan is a potent and selective MDM2 inhibitor. MDM2 inhibitor DS-3032b binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53 upon oral administration. By preventing this MDM2-p53 interaction, the proteosome-mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored. This results in the restoration of p53 signaling and leads to the p53-mediated induction of tumor cell apopto...
TP2281	p53 tumor suppressor fragment	Others	Others
	p53 tumor suppressor fragment (232-240) is a peptide with the sequence H2N-Lys-Tyr-Met-Cys-Asn-Ser-Ser-Cys-Met-OH, MW= 1066.3. p53 is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where i
T14554	BI-0252	Others	Others
	BI-0252 is an inhibitor of MDM2-p53 (IC50:4 nM). BI-0252 can induce tumor regressions in all animals of a mouse SJSA-1 xenograft. And it concomitant induction of the tumor protein p53 (TP53) target genes and markers of apoptosis.
T24466	Milademetan free base DS3032B,DS-3032,DS3032,DS 3032,DS 3032B,DS-3032B
	Milademetan (DS-3032b or DS-3032) is a potent and selective MDM2 inhibitor with potential antineoplastic activity. Milademetan (p.o.) binds to and prevents the binding of MDM2 protein to the transcriptional activation domain of the tumor suppressor protei
T36934	PK7242 (maleate) PK7242 (maleate)
	The protein p53, often called the 'guardian of the genome,' is a transcription factor that is activated in response to cellular stress (low oxygen levels, heat shock, DNA damage, etc.) and acts to prevent further proliferation of the stressed cell by promoting cell cycle arrest or apoptosis. Its role as a tumor suppressor is evident by the observation that approximately 50% of human tumors have mutated or non-functional p53. PK7242 is an inducer of reactivation of mutant p53 in cancer cells. In ...
T36108	YW3-56 (hydrochloride) (technical grade) YW3-56 (hydrochloride) (technical grade)
	YW3-56 is an inhibitor of protein arginine deiminase 2 (PAD2) and PAD4 (IC50s = 0.5-1 and 1-5 μM, respectively).1It inhibits the growth of U2OS osteosarcoma cells (IC50= ~2.5 μM) in a p53-dependent mannerviainduction of SESN2 and subsequent inhibition of mTORC1. YW3-56 (10 mg/kg) reduces tumor growth in an S-180 murine sarcoma tumor model. It also inhibits tumor growth in the 1883 MDA-MB-231 breast cancer bone metastasis mouse xenograft model.2 1.Wang, Y., Li, P., Wang, S., et al.Anticancer pept...
T68383	BIIB028
	BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to o...
T73257	USP7-IN-9
	USP7-IN-9是一种高效USP7抑制剂，其IC50值为40.8 nM。该化合物可诱导RS4; 11 细胞发生(apoptosis)，并使细胞周期在G0/G1及S期停滞。此外，USP7-IN-9能够降低癌症相关蛋白MDM2和DNMT1的表达量，同时增加抑癌蛋白p53与p21的表达量。
T35874	CC260
	CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosph...

化合物

tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus]

Cat.No: TP2299

Target: Others

Kevetrin hydrochloride

Cat.No: T3184

Synonym: Thioureidobutyronitrile HCl,thioureido butyronitrile hydrochloride,4-Isothioureidobutyronitrile hydrochloride

Target: Mdm2, p53

p53-MDM2-IN-1

Cat.No: T72026

Target: Mdm2, p53

Milademetan HCl (1398568-47-2 free base)

Cat.No: T28038

Synonym: Milademetan HCl,DS3032,DS 3032,DS-3032,DS3032b,DS-3032b,DS 3032b

p53 tumor suppressor fragment

Cat.No: TP2281

Target: Others

Cat.No: T14554

Target: Others

Milademetan free base

Cat.No: T24466

Synonym: DS3032B,DS-3032,DS3032,DS 3032,DS 3032B,DS-3032B

PK7242 (maleate)

Cat.No: T36934

Synonym: PK7242 (maleate)

YW3-56 (hydrochloride) (technical grade)

Cat.No: T36108

Synonym: YW3-56 (hydrochloride) (technical grade)

Cat.No: T68383

Cat.No: T73257

Cat.No: T35874

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02228	p53 Protein, Cynomolgus, Recombinant tumor protein p53,p53,T<...	Cynomolgus	E. coli
	p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag...
TMPY-01561	PIG3 Protein, Human, Recombinant (His) TP53I3,PIG3,tumor protein p53...	Human	E. coli
	Nutlin-3 variably induces apoptosis and cell cycle arrest in cancer cells while it shows low/absent cytotoxicity in normal cells, Nutlin-3 is a promising anti-cancer agent, which exhibits activity against a variety of cancers, including acute myeloid leukemia (AML). The important role of TP53I3/PIG3 in mediating the apoptotic activity of Nutlin-3 was underlined by knock-down experiments with siRNA specific for TP53I3/PIG3, which resulted in a significant decrease in the pro-apoptotic activity of...
TMPY-02030	CD82 Protein, Human, Recombinant (His) CD82 molecule,SAR2,R2,KAI-1,4F9,KAI1,C33,TSPAN27,ST6,IA4,GR1...	Human	HEK293 Cells
	CD82, also known as KAI-1, structurally belongs to tetraspanin family while categorised as metastasis suppressor gene on functional grounds. KAI1/CD82 is localized on cell membrane and form interactions with other tetraspanins, integrins and chemokines which are respectively responsible for cell migration, adhesion and signalling. Downregulation of CD82 expression is associated with the advanced stages of many human cancers and correlates with the acquisition of metastatic potential. Recent stud...
TMPK-01508	HLA-A02:01&B2M&P53* WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi) TP53,Antigen NY-CO-13,P53,MHC,HLA-A,BCC7,L...	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01538	HLA-A02:01&B2M&P53* WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated MHC,LFS1,Antigen NY-CO-13,HLA-A,BCC7,TP53,TRP53...	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01509	HLA-A02:01&B2M&P53* WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi) TRP53,HLA-A,TP53,LFS1,P53,MHC,FLJ...	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01442	HLA-A02:01&B2M&P53* WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled HLA-A,P53,TP53,LFS1,MHC,BCC7,TRP53	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein. p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01437	HLA-A02:01&B2M&P53* R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled FLJ92943,HLA-A,TP53,Antigen NY-CO-13,TRP53...	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01531	HLA-A02:01&B2M&P53* R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi) Antigen NY-CO-13,MHC,FLJ92943,TRP53,HLA-A,BCC7,T	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01532	HLA-A02:01&B2M&P53* R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi) Antigen NY-CO-13,BCC7,FLJ92943,HLA-A,LFS1,P53,T...	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPK-01552	HLA-A02:01&B2M&P53* R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated TP53,TRP53,HLA-A,MHC,Antigen NY-CO-13,BCC7...	Human	HEK293 Cells
	p53 is a tumor suppressor protein. Under stressful conditions, p53 tightly regulates cell growth by promoting apoptosis and DNA repair. When p53 becomes mutated, it loses its function, resulting in abnormal cell proliferation and tumor progression. Depending on the p53 mutation, it has been shown to form aggregates leading to negative gain of function of the protein.p53 mutant associated aggregation has been observed in several cancer tissues and has been shown to promote tumor growth.
TMPY-01125	MDMX Protein, Human, Recombinant (His) MRP1,MDM4, p53 regulator,HDMX,MDMX	Human	E. coli
	MDM4 (MDM4 Regulator Of P53, also known as MDMX) is a Protein Coding gene. This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus and shows structural similarity to p53-binding protein MDM2. MDM4 is a promising target for cancer therapy, as it is undetectable in most normal adult tissues but often upregulated in cancer cells to dampen p53 tumor-suppressor function. MDM4, an essential negative regulator of the P53 tumor ...
TMPY-00151	Alpha SNAP Protein, Human, Recombinant (His) N-ethylmaleimide-sensitive factor attachment protein	Human	E. coli
	NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. NAPA represents an anti-apoptotic protein that promotes resistance to cisplatin in cancer cells by inducing the degradation of the tumor suppressor p53. NAPA overexpression decreased the ubiquitination and degradation of s...
TMPJ-00697	NOL3 Protein, Human, Recombinant (GST) Nop30,Myp,NOP,Apoptosis Repressor With CARD,Nucleolar Pr...	Human	E. coli
	Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing.Isoform 2 may inhibit apoptosis.It has been shown to down-regulate the enzyme activities of caspase 2, caspase 8 and tumor protein p53.
TMPJ-00571	UBE2D3 Protein, Human, Recombinant Ubiquitin-protein ligase D3,Ubiquitin-conjugating e...	Human	E. coli
	UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase.
TMPY-02651	p63 Protein, Human, Recombinant (His & GST) p40,TP53L,RHS,B(p51A),p51,KET,NBP,B(p51B),OFC8,...	Human	Baculovirus Insect Cells
	Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53, p63, and p73 have similar features in their gene structures and functions. An animal model, p63-/- mice has been useful in difining the role p63 plays in the development and maintenance of stratified epithelial tissues. This p63 encoding protein p63 has a dramatic impact on replenishment of cutaneous epith...
TMPJ-00999	UBE2D1 Protein, Human, Recombinant (GST) Ubiquitin-conjugating enzyme E2(17)KB 1,UB,UbcH5,UBC5A,Stimu...	Human	E. coli
	Ubiquitin-conjugating enzyme E2 D1（UBE2D1）belongs to the ubiquitin-conjugating enzyme family. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transc...
TMPJ-01211	EDA2R Protein, Mouse, Recombinant (His) EDA-A2R,Tumor necrosis factor receptor superfamily ...	Mouse	HEK293 Cells
	Tumor necrosis factor receptor superfamily member 27, also known as XEDAR and EDA2R, is a type III transmembrane protein of the TNFR superfamily. EDA2R consists of extracellular domain (ECD) with 3 cysteine-rich repeats and a single transmembrane domain but lacks an N-terminal signal peptide. EDA2R is widely expressed, notably in embryonic basal epidermal cells and maturing hair follicles. Even though it does not contain a cytoplasmic death domain, EDA2R can associate with Fas and induce EDA‑A2 ...
TMPY-01890	CLIC4 Protein, Human, Recombinant (His) MTCLIC,chloride intracellular channel 4,p64H1,H1,huH1,CLIC4L	Human	E. coli
	Chloride intracellular channel protein 4, also known as Intracellular chloride ion channel protein p64H1 and CLIC4, is a member of the chloride channel CLIC family. It contains oneGST C-terminal domain. CLIC4 is a member of a family of intracellular chloride channels. It is regulated by p53, c-Myc, and tumor necrosis factor-alpha. CLIC4 is detected in epithelial cells from colon, esophagus and kidney (at protein level). CLIC4 has alternate cellular functions like a potential role in angio...
TMPY-03443	NDRG1 Protein, Human, Recombinant (His) TARG1,PROXY1,RIT42,NDR1,DRG1,RTP,TDD5,CMT4D,CAP43,NMSL,N-myc...	Human	E. coli
	NDRG1 gene is a member of the N-Myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Mutations in the NDRG1 gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. NDRG1 is a stress-responsive pro...
TMPY-04550	JNK2 Protein, Human, Recombinant (His) JNK2α,SAPK1a,PRKM9,JNK2β,JNK2,SAPK,JNK2BETA,mitogen-activate...	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase 9 (MAPK9), also well known as c-Jun N-terminal kinase (JNK2), is a member of the MAP kinase subfamily belonging to the protein kinase superfamily. MAPK9 responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating some transcription factors, such as c-Jun and ATF2. The crystal structure of human JNK2 complexed with an indazole inhibitor by applying a high-throughput protein engineering and surface-site mutagenesis approach. A n...
TMPY-02135	S100A16 Protein, Human, Recombinant S100F,DT1P1A7,S100 calcium binding protein A16,MGC1...	Human	E. coli
	S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-hand motifs. S100 proteins are cell- and tissue-specific and are involved in many intra- and extracellular processes through interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has be...
TMPJ-00696	NOL3 Protein, Human, Recombinant Apoptosis Repressor With CARD,Nucleolar Protein of ...	Human	E. coli
	Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants encoding different isoforms have been found for this gene. So far, Nucleolar protein 3 has show to have two Isoforms. Isoform 1 may be involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death. It inhibits extrinsic apoptotic pathways through two different ways. Firstly, it by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex ...
TMPY-04417	DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST) DAPK,death-associated protein kinase 1,ROCO3	Human	Baculovirus Insect Cells
	Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g...
TMPY-04547	PBK/TOPK Protein, Human, Recombinant (His) HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK	Human	Baculovirus Insect Cells
	PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun...
TMPY-01204	SMYD2 Protein, Human, Recombinant (His) ZMYND14,SET and MYND domain containing 2,HSKM-B,KMT3C	Human	Baculovirus Insect Cells
	SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly exp...
TMPH-01273	TRIP12 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damag...
TMPY-00950	WISP1/CCN4 Protein, Human, Recombinant (His) WISP1c,WISP1i,CCN4,WNT1 inducible signaling pathway prot...	Human	HEK293 Cells
	CCN4/Wnt-induced secreted protein 1 (WISP1) is a secreted, cysteine-rich, heparin-binding glycoprotein, belonging to the CCN (CTGF/CYR61/NOV) family of growth factors, and is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, tissue repair, and regulation of extracellular matrix. Members of the CCN family demonstrate high structural homology sharing four conserved cysteine-rich modular domains: an IGFBP (insulin-like growth factor-binding) domain, a ...
TMPY-04260	p38 Protein, Human, Recombinant (His) mitogen-activated protein kinase 14,CSPB1,PRKM14,RK...	Human	Baculovirus Insect Cells
	MAPK14 contains 1 protein kinase domain and belongs to the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK14 can be detected in the brain, heart, placenta, pancreas, and skeletal muscle and it is expressed to a lesser extent in the lung, liver, and kidney. MAPK14 is activated by various environmental stresses ...
TMPH-02631	PRKN Protein, Mouse, Recombinant (GST)	Mouse	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...
TMPH-01263	PRKN Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Substrates include SYT11 and VDAC1. Other substrates are BCL2, CCNE1, GPR37, RHOT1/MIRO1, MFN1, MFN2, STUB1, SNCAIP, SEPTIN5, TOMM20, USP30, ZNF746, MIRO1 and AIMP2. Mediates monoubiquitination as well as 'Lys-6', 'Lys-11', 'Lys-48'-linked and 'Lys-63'-linked polyubiquitination of substrates depending on the context. Participates in the removal and/or det...

重组蛋白

p53 Protein, Cynomolgus, Recombinant

Cat.No: TMPY-02228

Species: Cynomolgus

Expression System: E. coli

PIG3 Protein, Human, Recombinant (His)

Cat.No: TMPY-01561

Species: Human

Expression System: E. coli

CD82 Protein, Human, Recombinant (His)

Cat.No: TMPY-02030

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01508

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01538

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01509

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 WT (HMTEVVRRC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01442

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi), PE-Labeled

Cat.No: TMPK-01437

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Tetramer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01531

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi)

Cat.No: TMPK-01532

Species: Human

Expression System: HEK293 Cells

HLA-A*02:01&B2M&P53 R175H (HMTEVVRHC) Monomer Protein, Human, MHC (His & Avi), Biotinylated

Cat.No: TMPK-01552

Species: Human

Expression System: HEK293 Cells

MDMX Protein, Human, Recombinant (His)

Cat.No: TMPY-01125

Species: Human

Expression System: E. coli

Alpha SNAP Protein, Human, Recombinant (His)

Cat.No: TMPY-00151

Species: Human

Expression System: E. coli

NOL3 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00697

Species: Human

Expression System: E. coli

UBE2D3 Protein, Human, Recombinant

Cat.No: TMPJ-00571

Species: Human

Expression System: E. coli

p63 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02651

Species: Human

Expression System: Baculovirus Insect Cells

UBE2D1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-00999

Species: Human

Expression System: E. coli

EDA2R Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01211

Species: Mouse

Expression System: HEK293 Cells

CLIC4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01890

Species: Human

Expression System: E. coli

NDRG1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03443

Species: Human

Expression System: E. coli

JNK2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04550

Species: Human

Expression System: Baculovirus Insect Cells

S100A16 Protein, Human, Recombinant

Cat.No: TMPY-02135

Species: Human

Expression System: E. coli

NOL3 Protein, Human, Recombinant

Cat.No: TMPJ-00696

Species: Human

Expression System: E. coli

DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)

Cat.No: TMPY-04417

Species: Human

Expression System: Baculovirus Insect Cells

PBK/TOPK Protein, Human, Recombinant (His)

Cat.No: TMPY-04547

Species: Human

Expression System: Baculovirus Insect Cells

SMYD2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01204

Species: Human

Expression System: Baculovirus Insect Cells

TRIP12 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01273

Species: Human

Expression System: E. coli

WISP1/CCN4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00950

Species: Human

Expression System: HEK293 Cells

p38 Protein, Human, Recombinant (His)

Cat.No: TMPY-04260

Species: Human

Expression System: Baculovirus Insect Cells

PRKN Protein, Mouse, Recombinant (GST)

Cat.No: TMPH-02631

Species: Mouse

Expression System: E. coli

PRKN Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01263

Species: Human

Expression System: E. coli

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